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ACP Journal Club |19 January 2009

Review: Inhaled anticholinergics increase risk for major cardiovascular events in chronic obstructive pulmonary disease

Matthew B. Stanbrook, MD, PhD

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Singh S, Loke YK, Furberg CD. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. JAMA. 2008;300:1439-50. 18812535

Cardiology:

Pulmonology:

See alsoTiotropium reduced exacerbations but not rate of FEV1 decline in patients with COPD using other respiratory medications
The review by Singh and colleagues and the trial by Tashkin and colleagues were done to address uncertainty about the risks and benefits of inhaled anticholinergic therapy in COPD. However, understanding the discrepant findings is a challenge. Why did the meta-analysis show a 52% increase in myocardial infarction...
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Stanbrook MB. Review: Inhaled anticholinergics increase risk for major cardiovascular events in chronic obstructive pulmonary disease. Ann Intern Med. 2009;150:JC1–6. doi: 10.7326/0003-4819-150-2-200901200-02006

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Published: Ann Intern Med. 2009;150(2):JC1-6.

DOI: 10.7326/0003-4819-150-2-200901200-02006

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