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ACP Journal Club |17 February 2009

Review: Low-molecular-weight heparin reduces risk for venous thromboembolism in adults with leg immobilization

Benilde Cosmi, MD, PhD

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Testroote M, Stigter W, de Visser DC, Janzing H. Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-leg immobilization. Cochrane Database Syst Rev. 2008;4:CD006681. 18843725

Emergency Med:

Hematol/Thrombo:

Lower-extremity injuries distal to the knee (fractures, ligament and cartilage injuries of the knee and ankle, and rupture of the Achilles tendon) requiring immobilization in an ambulant setting are common at all ages and increase risk for VTE. Wide practice variations in thromboprophylaxis exist, and not all guidelines recommend prophylaxis because of the scarcity of methodologically adequate trials. Although the American College of Chest Physicians 2008 guidelines do...
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Cosmi B. Review: Low-molecular-weight heparin reduces risk for venous thromboembolism in adults with leg immobilization. Ann Intern Med. 2009;150:JC2–4. doi: https://doi.org/10.7326/0003-4819-150-4-200902170-02004

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Published: Ann Intern Med. 2009;150(4):JC2-4.

DOI: 10.7326/0003-4819-150-4-200902170-02004

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