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ACP Journal Club |17 February 2009

Telmisartan did not reduce a composite of CV death, MI, HF, or stroke in high-risk patients intolerant to ACE inhibitors

Robin J. Taylor, MD

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Yusuf S for the TRANSCEND Investigators. Effects of the angiotensin-receptor blocker telmisartan on cardiovascular events in high-risk patients intolerant to angiotensin-converting enzyme inhibitors: a randomised controlled trial. Lancet. 2008;372:1174-83. 18757085

Cardiology:

Most patients with CV disease or high-risk diabetes but preserved left ventricular function are given ACE inhibitors, based on the HOPE study, which showed reduction in CV morbidity and mortality (1). The ONTARGET trial found that telmisartan was noninferior in the minority of patients who were intolerant to ACE inhibitors, primarily because of cough (2).
It is thus surprising that TRANSCEND did not find telmisartan to be...
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Taylor RJ. Telmisartan did not reduce a composite of CV death, MI, HF, or stroke in high-risk patients intolerant to ACE inhibitors. Ann Intern Med. 2009;150:JC2–6. doi: 10.7326/0003-4819-150-4-200902170-02006

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Published: Ann Intern Med. 2009;150(4):JC2-6.

DOI: 10.7326/0003-4819-150-4-200902170-02006

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