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ACP Journal Club |18 August 2009

Both typical and atypical antipsychotic agents were associated with increased risk for sudden cardiac death

Steven Marder, MD

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Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med. 2009;360:225-35. 19144938

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The newer atypical antipsychotic medications, as a group, are associated with risk for sudden cardiac death similar to that of older typical drugs. The comparative risk among these agents, which is dose-related, appears to be linked to their likelihood of prolonging the QT interval on electrocardiography. Overall, the incidence rate in the population treated with an antipsychotic agent was 2.9 events per 1000 patient-years, which suggests that such events are...
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Marder S. Both typical and atypical antipsychotic agents were associated with increased risk for sudden cardiac death. Ann Intern Med. 2009;151:JC2–12. doi: 10.7326/0003-4819-151-4-200908180-02012

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Published: Ann Intern Med. 2009;151(4):JC2-12.

DOI: 10.7326/0003-4819-151-4-200908180-02012

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