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ACP Journal Club |15 September 2009

Review: Low-dose corticosteroids improve outcomes in acute lung injury and the acute respiratory distress syndrome

Niall D. Ferguson, MD, MSc

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Tang BM, Craig JC, Eslick GD, Seppelt I, McLean AS. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med. 2009;37:1594-603. 19325471

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The meta-analysis by Tang and colleagues is methodologically sound but is vulnerable to criticism applicable to every meta-analysis—the results are only as credible as the data from the individual studies that are included. The choice to include 5 cohort studies is likely to draw criticism because such studies are subject to treatment-indication bias (patients receive the therapy in a nonrandom fashion based on certain...
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Ferguson ND. Review: Low-dose corticosteroids improve outcomes in acute lung injury and the acute respiratory distress syndrome. Ann Intern Med. 2009;151:JC3–12. doi: 10.7326/0003-4819-151-6-200909150-02012

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Published: Ann Intern Med. 2009;151(6):JC3-12.

DOI: 10.7326/0003-4819-151-6-200909150-02012

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