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ACP Journal Club |20 July 2010

Review: Enteral nutrition reduces mortality, multiple organ failure, and systemic infection more than TPN in acute pancreatitis

Shahnaz Sultan, MD, MHSc; Chris E. Forsmark, MD

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Al-Omran M, Albalawi ZH, Tashkandi MF, Al-Ansary LA. Enteral versus parenteral nutrition for acute pancreatitis. Cochrane Database Syst Rev. 2010;(1):CD002837. 20091534

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Evidence accumulating over the past 2 decades suggests that EN is safer and more effective than TPN for providing nutrition to patients with acute pancreatitis. In the methodologically rigorous Cochrane review and meta-analysis, Al-Omran and colleagues found that EN was associated with a 50% relative risk reduction in mortality compared with TPN. This translates to a number-needed-to-treat of 13. Further, they found reductions in MOF, systemic infection, and operative intervention with EN compared with TPN.
However, the...
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Sultan S, Forsmark CE. Review: Enteral nutrition reduces mortality, multiple organ failure, and systemic infection more than TPN in acute pancreatitis. Ann Intern Med. 2010;153:JC1–6. doi: https://doi.org/10.7326/0003-4819-153-2-201007200-02006

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Published: Ann Intern Med. 2010;153(2):JC1-6.

DOI: 10.7326/0003-4819-153-2-201007200-02006

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Related Topics
Gastroenterology/Hepatology
Infectious Disease
Multi-Organ Failure and Sepsis
Pancreatic Disease
Pulmonary/Critical Care

Gastroenterology/Hepatology, Infectious Disease, Multi-Organ Failure and Sepsis, Pancreatic Disease, Pulmonary/Critical Care.

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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