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ACP Journal Club |20 July 2010

Higher “normal” glycated hemoglobin levels were associated with increased risk for diabetes, CVD, stroke, and mortality in adults

Steven A. Smith, MD

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Selvin E, Steffes MW, Zhu H, et al. Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults. N Engl J Med. 2010;362:800-11. 20200384

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Selvin and colleagues found that higher HbA1c levels were associated with risk for diabetes, which is consistent with other population studies in individuals without diabetes (1). This study adds support for the use of HbA1c levels for screening and diagnosis of diabetes (2) and supports the possible association of HbA1c levels with cardiovascular events (3). Despite the establishment of the National Glycohemoglobin Standardization Program (NGSP) (4), there is...
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Smith SA. Higher “normal” glycated hemoglobin levels were associated with increased risk for diabetes, CVD, stroke, and mortality in adults. Ann Intern Med. 2010;153:JC1–13. doi: 10.7326/0003-4819-153-2-201007200-02013

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Published: Ann Intern Med. 2010;153(2):JC1-13.

DOI: 10.7326/0003-4819-153-2-201007200-02013

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