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ACP Journal Club |21 September 2010

Review: β-agonists increase asthma-related intubations and deaths in patients with asthma

Jay Peters, MD

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Salpeter SR, Wall AJ, Buckley NS. Long-acting beta-agonists with and without inhaled corticosteroids and catastrophic asthma events. Am J Med. 2010;123:322-8. 20176343

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Pulmonology:

The well-done meta-analysis by Salpeter and colleagues shows that use of LABAs without concomitant ICSs increases the risk for intubation or death (OR 2.2; CI 1.1 to 4.36). This warning is timely, as a recent survey of > 1000 physicians showed that > 2% of specialists and 11% of primary care physicians reported use of LABA monotherapy as the preferred treatment for mild-to-moderate asthma (1).
The results of the meta-analysis conflict with several recent studies...
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Peters J. Review: β-agonists increase asthma-related intubations and deaths in patients with asthma. Ann Intern Med. 2010;153:JC3–5. doi: 10.7326/0003-4819-153-6-201009210-02005

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Published: Ann Intern Med. 2010;153(6):JC3-5.

DOI: 10.7326/0003-4819-153-6-201009210-02005

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