BRUCE POLSKY, M.D.; JONATHAN W. M. GOLD, M.D.; ESTELLA WHIMBEY, M.D.; JOSÉ DRYJANSKI, M.D.; ARTHUR E. BROWN, M.D.; GERALD SCHIFFMAN, Ph.D.; DONALD ARMSTRONG, M.D.
Eighteen episodes of community-acquired bacterial pneumonia were diagnosed in 13 patients among 336 with the acquired immunodeficiency syndrome (AIDS) cared for at Memorial Sloan-Kettering Cancer Center since 1979. Bacterial pathogens isolated in 16 of 18 episodes were Haemophilus influenzae in 8, Streptococcus pneumoniae in 6, group B streptococcus in 1, and Branhamella catarrhalis in 1. Eight episodes were presumed Pneumocystis carinii pneumonia until cultures obtained at bronchoscopy confirmed a bacterial cause. Specific antibacterial therapy was curative in 16 of 18 episodes; 2 patients died. Given an estimated yearly incidence of pneumococcal pneumonia in the general population of 2.6/1000, 1.09 cases were expected in our patients with AIDS; we saw 6 (p = 0.001), for an attack rate of 17.9/1000. Bacteria associated with B-cell defects should be anticipated when formulating empiric antibiotic therapy, pending a definitive diagnosis, for pulmonary infiltrates in patients with AIDS.
POLSKY B, GOLD JWM, WHIMBEY E, et al. Bacterial Pneumonia in Patients with the Acquired Immunodeficiency Syndrome. Ann Intern Med. 1986;104:38–41. doi: 10.7326/0003-4819-104-1-38
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Published: Ann Intern Med. 1986;104(1):38-41.
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