AARON SPITAL, M.D.
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To the editor: In the August issue, Hricik (1) suggests that volume status is an important factor in captopril-induced functional renal failure that occurs when perfusion pressure to the total renal mass is greatly reduced. Thus, in a patient with renal-artery stenosis after transplantation, Hricik has shown that after 25 mg of captropril there was a 49% reduction in inulin clearance when the patient was sodium depleted, and only a 14% reduction in inulin clearance when the patient was sodium repleted. However, it is hard to understand the marked rise in serum creatinine level that was noted the same day
SPITAL A. Captopril-Induced Renal Insufficiency. Ann Intern Med. 1986;104:126–127. doi: 10.7326/0003-4819-104-1-126
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Published: Ann Intern Med. 1986;104(1):126-127.
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