LAURENT JACOB; PASCALE MAISONNEUVE; DANIEL SERENI; YVETTE SULTAN; CLAUDE LAROCHE; CLAIRE GAZENGEL
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To the editor: We wish to report the first fatal cases of the acquired immunodeficiency syndrome (AIDS) in France in two patients with severe hemophilia A who were treated with factor VIII concentrate from foreign and French suppliers. The two patients had opportunistic infection and a pronounced defect in cell-mediated immunity: a marked decrease of T4 lymphocytes (101 and 79/mm3, respectively) with a depressed helper (T4)/suppressor (T8) ratio (0. 2 and 0.5, respectively).
Antibodies to the lymphadenopathy-associated virus/human T-lymphotropic virus type III (LAV/HTLV-III) were found in both patients by an indirect immunofluorescent assay. Antibodies to the virus were found in
JACOB L, MAISONNEUVE P, SERENI D, SULTAN Y, LAROCHE C, GAZENGEL C. Possible Genetic Susceptibility to the Acquired Immunodeficiency Syndrome in Hemophiliacs. Ann Intern Med. ;104:130. doi: 10.7326/0003-4819-104-1-130_1
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Published: Ann Intern Med. 1986;104(1):130.
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