KARL E. ANDERSON, M.D.; SHIGERU SASSA, M.D.; ATTALLAH KAPPAS, M.D.
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To the editor: Mustajoki (1) claims to have described a new variant of acute intermittent porphyria. This finding would be quite important if proved unequivocally, but such a claim is premature from the data presented. First, Mustajoki states that "no hematologic or other cause was found that could secondarily have raised low [porphobilinogen deaminase (also known as uroporphyrinogen-I synthase)] activity to normal." The patient of Case III-1, however, with the highest porphobilinogen deaminase activity among the subjects with porphyria, had a reticulocyte count of 5%, and three others had counts of 2.1% to 2.5%. An increased reticulocyte count is certainly
ANDERSON KE, SASSA S, KAPPAS A. Acute Intermittent Porphyria. Ann Intern Med. 1981;95:784–785. doi: https://doi.org/10.7326/0003-4819-95-6-784
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Published: Ann Intern Med. 1981;95(6):784-785.
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