Leonard H. Calabrese, DO
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To the Editor: The article by MacDonald and colleagues (1) presents reassuring evidence that positive sequential enzyme-linked immunosorbent assay (ELISA) and Western blot are highly specific for human immunodeficiency virus (HIV) when testing in a low-incidence population, but it tends to understate the importance of the problem of the high frequency of indeterminate reactions. As a physician caring for patients with HIV-related disease, I have had many patients referred for further evaluation because they were found to be ELISA positive and Western blot indeterminate. I have been repeatedly impressed that, even in the absence of recognizable HIV-related risk factors, these
Calabrese LH. Indeterminate Reactors to Tests for Human Immunodeficiency Virus (HIV). Ann Intern Med. ;111:95. doi: 10.7326/0003-4819-111-1-95_1
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Published: Ann Intern Med. 1989;111(1):95.
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