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ACP Journal Club |20 March 2012

Less-frequent warfarin dose assessment was noninferior for patients with stable INRs

Francesco Dentali, MD

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Schulman S, Parpia S, Stewart C, et al. Warfarin dose assessment every 4 weeks versus every 12 weeks in patients with stable international normalized ratios: a randomized trial. Ann Intern Med. 2011;155:653-9. 22084331

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Hematol/Thrombo:

Warfarin prevents thromboembolic complications in patients with venous thromboembolism, atrial fibrillation, and valvular heart disease; however, patients taking warfarin and other vitamin K antagonists (VKAs) need monitoring and dose adjustment. The American College of Chest Physicians guidelines recommend a maximum monitoring interval ≤ 4 weeks (1). However, about one third of patients have stable INR values, and less frequent INR monitoring is potentially...
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Dentali F. Less-frequent warfarin dose assessment was noninferior for patients with stable INRs. Ann Intern Med. 2012;156:JC3–3. doi: 10.7326/0003-4819-156-6-201202210-02003

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Published: Ann Intern Med. 2012;156(6):JC3-3.

DOI: 10.7326/0003-4819-156-6-201202210-02003

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