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Letters |21 February 2012

Venous Thromboembolism Prophylaxis

Todd E.H. Hecht, MD

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Potential Conflicts of Interest: None disclosed.
  • From Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
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TO THE EDITOR:
I read with great interest Lederle and colleagues' systematic review (1) on venous thromboembolism (VTE) prophylaxis. The authors conclude that heparin prophylaxis resulted “in little or no net benefit.” This is in contrast to an earlier meta-analysis by Wein and colleagues (2) that used many of the same studies in medical patients and patients with stroke. I believe that Lederle and colleagues reached this conclusion erroneously.
First, the authors' decision to eliminate asymptomatic deep venous thrombosis (DVT) from their analysis accounts for a substantial bias against the efficacy of VTE prophylaxis. The authors do not provide the...
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Hecht TE. Venous Thromboembolism Prophylaxis. Ann Intern Med. 2012;156:324. doi: https://doi.org/10.7326/0003-4819-156-4-201202210-00020

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Published: Ann Intern Med. 2012;156(4):324.

DOI: 10.7326/0003-4819-156-4-201202210-00020

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