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ACP Journal Club |21 February 2012

Adding procalcitonin-guided therapy to standard care did not reduce mortality in critically ill patients

Henry S. Sacks, PhD, MD

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Jensen JU, Hein L, Lundgren B, et al; The Procalcitonin And Survival Study (PASS) Group. Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: a randomized trial. Crit Care Med. 2011;39:2048-58. 21572328

Infectious Disease:

Critical Care:

PCT levels have been shown to have some diagnostic and prognostic value, but questions about their use remain. Higher PCT levels suggest bacterial as opposed to viral infection, and PCT-guided therapies have been shown to reduce use of antibiotics without adverse effects in patients with community-acquired pneumonia and acute exacerbations of chronic bronchitis (1).
Disappointingly,...
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Sacks HS. Adding procalcitonin-guided therapy to standard care did not reduce mortality in critically ill patients. Ann Intern Med. 2012;156:JC2–6. doi: 10.7326/0003-4819-156-4-201202210-02006

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Published: Ann Intern Med. 2012;156(4):JC2-6.

DOI: 10.7326/0003-4819-156-4-201202210-02006

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