RALPH E. BERNSTEIN, M.B.
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To the editor: Boden and colleagues (1) have indicated the value of checking glycosylated hemoglobin (glycohemoglobin) during stable and deteriorating periods of diabetic control but conclude that hemoglobin (Hb) A1 assay is not useful for detecting rapidly improving metabolic states. Nevertheless, this information can be obtained by a simple stratagem, using the same analytic method of cation-exchange chromatography. It involves centrifuging an aliquot of the blood and preparing a dialysed hemolysate for Hb A1 assay of the top 10% fraction of the erythrocyte column (2); this contains reticulocytes (the 0.9% of normal whole blood is enhanced to 6% or more
BERNSTEIN RE. Glycosylated Hemoglobin and Monitoring of Diabetic Control. Ann Intern Med. ;93:380. doi: 10.7326/0003-4819-93-2-380_1
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Published: Ann Intern Med. 1980;93(2):380.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism.
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