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Letters |4 September 2012

Dose Response to Vitamin D Supplementation in Postmenopausal Women

Arthur B. Chausmer, MD, PhD

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  • From Johns Hopkins University School of Medicine, Baltimore, MD 21224.

    Potential Conflicts of Interest: None disclosed.

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TO THE EDITOR:
I read the recent article by Gallagher and colleagues (1) with interest. Although it correctly stated that there was a relationship between the serum 25-hydroxyvitamin D (25-[OH]D) intermediate metabolite and the oral dose, there are some other important points to consider. It is important to note that, contrary to popular opinion, the level of circulating 25-(OH)D should not be considered an appropriate indicator of true vitamin D sufficiency or insufficiency. Because the total body load of any of the vitamin D metabolites has yet to be quantitatively assessed, there is no way of knowing whether there is a deficiency; what relationship, if any, exists between blood levels and total body storage; or what the relationship between active and inactive metabolites might be. These are key points that need to be addressed.
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Chausmer AB. Dose Response to Vitamin D Supplementation in Postmenopausal Women. Ann Intern Med. ;157:384. doi: 10.7326/0003-4819-157-5-201209040-00014

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Published: Ann Intern Med. 2012;157(5):384.

DOI: 10.7326/0003-4819-157-5-201209040-00014

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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