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ACP Journal Club |18 September 2012

Review: Teriparatide reduces fractures in postmenopausal women with osteoporosis

Bruce E. Johnson, MD

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Han SL, Wan SL. Effect of teriparatide on bone mineral density and fracture in postmenopausal osteoporosis: meta-analysis of randomised controlled trials. Int J Clin Pract. 2012;66:199-209. 22257045

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The meta-analysis by Han and colleagues highlights some important findings about treatment of postmenopausal women with osteoporosis. They found that teriparatide, an analogue of parathyroid hormone, functions as an anabolic agent and increases BMD at both vertebrae and hip. This increased BMD resulted in fewer fractures at both sites, the outcome that really matters. In an important caveat, the authors determined that the increase in BMD was greater in women taking...
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Johnson BE. Review: Teriparatide reduces fractures in postmenopausal women with osteoporosis. Ann Intern Med. 2012;157:JC3–4. doi: 10.7326/0003-4819-157-6-201209180-02004

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Published: Ann Intern Med. 2012;157(6):JC3-4.

DOI: 10.7326/0003-4819-157-6-201209180-02004

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