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Letters |18 September 2012

Antidiuretic Hormone Antagonist to Reduce Cystine Stone Formation

Hans de Boer, MD, PhD; Anita Roelofsen, MD; Pim M.W. Janssens, PhD

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Author, Article, and Disclosure Information
  • From Rijnstate Hospital, 6881 NR Arnhem, the Netherlands.

    Potential Conflicts of Interest: None disclosed.

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Background: Cystinuria is the most common inherited cause of recurrent kidney stones (1). Its principal disorder is impaired reabsorption of cystine in the proximal renal tubule. As a result, large amounts of cystine are excreted in urine, kidney stones form because cystine is poorly soluble, and the patient experiences many urologic interventions. Measures to prevent stone formation include changing the diet to reduce cystine excretion, diluting urine to a lower cystine concentration, and making the urine alkaline to improve cystine solubility. Cystine-binding thiol drugs also improve cystine solubility but need to be discontinued because of adverse effects in 30% to 60% of cases (1).
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de Boer H, Roelofsen A, Janssens PM. Antidiuretic Hormone Antagonist to Reduce Cystine Stone Formation. Ann Intern Med. ;157:459–460. doi: 10.7326/0003-4819-157-6-201209180-00023

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Published: Ann Intern Med. 2012;157(6):459-460.

DOI: 10.7326/0003-4819-157-6-201209180-00023

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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