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ACP Journal Club |20 November 2012

CKD-EPI eGFR categories were better than MDRD categories for predicting mortality in a range of populations

Chi-yuan Hsu, MD, MSc

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Matsushita K, Mahmoodi BK, Woodward M, et al; Chronic Kidney Disease Prognosis Consortium. Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate. JAMA. 2012;307:1941-51. 22570462

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Nephrology:

A major strength of the study by Matsushita and colleagues is the broad range of populations represented. The analysis is a tour de force and, together with previous research (1), clearly establishes that the CKD-EPI equation overcomes one of the key limitations of the MDRD equation—the tendency to underestimate GFR in persons with preserved renal function. Does this advantage warrant wholesale replacement...
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Hsu C. CKD-EPI eGFR categories were better than MDRD categories for predicting mortality in a range of populations. Ann Intern Med. 2012;157:JC5–12. doi: 10.7326/0003-4819-157-10-201211200-02012

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Published: Ann Intern Med. 2012;157(10):JC5-12.

DOI: 10.7326/0003-4819-157-10-201211200-02012

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