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ACP Journal Club |19 February 2013

In recently postmenopausal women, HRT reduced a composite of death, MI, or heart failure at 10 years

Angela M. Cheung, MD, PhD

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Schierbeck LL, Rejnmark L, Tofteng CL, et al. Effect of hormone replacement therapy on cardiovascular events in recently postmenopausal women: randomised trial. BMJ. 2012;345:e6409. 23048011

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10 years have passed since the Women's Health Initiative (WHI) was first released (1), and confusion over appropriate use of HRT in postmenopausal women remains. WHI is the largest long-term RCT (> 27, 000 women, mean follow-up 5 to 7 y) investigating the effects of HRT in postmenopausal women (1−3). Both the estrogen-only and estrogen-plus-progesterone groups were stopped early due to concerns about harm. However, because women in WHI were older...
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Cheung AM. In recently postmenopausal women, HRT reduced a composite of death, MI, or heart failure at 10 years. Ann Intern Med. 2013;158:JC2–2. doi: https://doi.org/10.7326/0003-4819-158-4-201302190-02002

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Published: Ann Intern Med. 2013;158(4):JC2-2.

DOI: 10.7326/0003-4819-158-4-201302190-02002

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