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ACP Journal Club |19 February 2013

Review: Cholinesterase inhibitors do not reduce progression to dementia from mild cognitive impairment

Nasseer Masoodi, MD, MBA, FACP

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Russ TC, Morling JR. Cholinesterase inhibitors for mild cognitive impairment. Cochrane Database Syst Rev. 2012;(9):CD009132. 22972133

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The results of the review by Russ and Morling come as no surprise since a previous meta-analysis showed that ChEIs had limited, if any, effect on mild cognitive impairment (1). Clinicians continue to debate whether significant improvements in cognitive function in mild to moderate Alzheimer dementia with ChEIs translate into clinical significance because many studies have short treatment periods (usually 6 mo) (1). Russ and Morling assessed the efficacy, safety, and tolerability of ChEIs for...
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Masoodi N. Review: Cholinesterase inhibitors do not reduce progression to dementia from mild cognitive impairment. Ann Intern Med. 2013;158:JC2–3. doi: 10.7326/0003-4819-158-4-201302190-02003

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Published: Ann Intern Med. 2013;158(4):JC2-3.

DOI: 10.7326/0003-4819-158-4-201302190-02003

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