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ACP Journal Club |19 March 2013

Amoxicillin/clavulanate vs placebo: more exacerbation cures, fewer recurrences in mild-to-moderate COPD

Sandra G. Adams, MD, MS; Jay I. Peters, MD

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Llor C, Moragas A, Hernández S, Bayona C, Miravitlles M. Efficacy of antibiotic therapy for acute exacerbations of mild to moderate chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186:716-23. 22923662

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The well-done RCT by Llor and colleagues studied an unresolved clinical question: What is the role of antibiotics in outpatients with acute exacerbations of COPD? The study clearly showed that the antibiotic group had higher rates of improvement and/or cure and a longer median time to the next exacerbation. It uniquely adds to the literature because it studied a well-defined population managed in a...
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Adams SG, Peters JI. Amoxicillin/clavulanate vs placebo: more exacerbation cures, fewer recurrences in mild-to-moderate COPD. Ann Intern Med. 2013;158:JC3. doi: https://doi.org/10.7326/0003-4819-158-6-201303190-02003

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Published: Ann Intern Med. 2013;158(6):JC3.

DOI: 10.7326/0003-4819-158-6-201303190-02003

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