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ACP Journal Club |16 April 2013

Supplementation with vitamin D did not reduce cartilage volume loss or pain in knee osteoarthritis

Jean-Yves Reginster, MD, PhD; Franz Pelousse, MD

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McAlindon T, LaValley M, Schneider E, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013;309:155-62. 23299607

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In patients with symptomatic osteoarthritis (OA) of the knee, does supplementation with vitamin D reduce cartilage loss and knee pain?
Randomized placebo-controlled trial (RCT). ClinicalTrials.gov NCT00306774.
Concealed.*
Blinded* (patients and clinicians).
2 years.
Tufts Medical Center, Boston, Massachusetts, USA.
146 patients ≥ 45 years of age (mean age 62 y, 61% women) with symptomatic knee OA (American College of Rheumatology criteria: long-term knee pain and ≥ 1 osteophyte on knee radiograph [equivalent to Kellgren-Lawrence grade 2]), mild or worse weight-bearing pain (Western Ontario and McMaster Universities [WOMAC] pain subscale), and pain or discomfort referable to the knee joint. Exclusion criteria included use of vitamin D supplement > 800 IU/d, serum calcium level > 10.5 mg/dL, hypercalciuria (spot urine calcium–creatinine ratio > 0.4), use of supplements or medications with possible effects on cartilage (e.g., glucosamine), intraarticular therapies within 3 months, use of long-term oral corticosteroids, lymphoma, sarcoidosis, tuberculosis, hyperparathyroidism, malabsorption disorders, glomerular filtration rate < 30 mL/min/1.73 m2, or inflammatory joint disease.
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Reginster J, Pelousse F. Supplementation with vitamin D did not reduce cartilage volume loss or pain in knee osteoarthritis. Ann Intern Med. 2013;158:JC9. doi: 10.7326/0003-4819-158-8-201304160-02009

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Published: Ann Intern Med. 2013;158(8):JC9.

DOI: 10.7326/0003-4819-158-8-201304160-02009

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