Skip Navigation
Menu
Letters |18 June 2013

Chlorthalidone Versus Hydrochlorothiazide

Paula T. Einhorn, MD, MS; William C. Cushman, MD; Paul K. Whelton, MB, MD, MSc; for the ALLHAT Collaborative Research Group

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • From National Heart, Lung, and Blood Institute, Bethesda, Maryland; Veterans Affairs Medical Center, Memphis, Tennessee; and Tulane University, New Orleans, Louisiana.

    Disclaimer: Dr. Einhorn is a full-time employee of the National Heart, Lung, and Blood Institute. The views expressed in this letter do not necessarily represent the views of the National Heart, Lung, and Blood Institute; National Institutes of Health; or any other government entity.

    Acknowledgment: The authors acknowledge scientific input from Drs. Jeffrey Cutler, Barry Davis, and Jackson Wright and administrative assistance from Dr. Ellen Breckenridge. The ALLHAT Collaborative Research Group was supported by contracts NO1-HC-35130 and HHSN268201100036C with the National Heart, Lung, and Blood Institute. The ALLHAT investigators acknowledge study medications contributed by Pfizer (amlodipine and doxazosin), AstraZeneca (atenolol and lisinopril), and Bristol-Myers Squibb (pravastatin) and financial support provided by Pfizer.

    Potential Conflicts of Interest: Dr. Cushman: Consultancy: Novartis, Takeda, AstraZeneca, Merck, Daiichi-Sankyo; Other: Dr. Cushman has received honoraria from Novartis and Takeda.

×
FULL TEXT
TO THE EDITOR:
We would like to clarify that the main results paper of ALLHAT (1) included information on serum potassium levels and supplementation by randomized treatment group (chlorthalidone, n = 15 255; amlodipine, n = 9048; lisinopril, n = 9054; and doxazosin, n = 9061). ALLHAT also explored the clinical significance of incident hypo- and hyperkalemia (2). Similar to Dhalla and coworkers’ findings (3), in our practice-based trial, severe hypokalemia (potassium levels <3.2 mmol/L, regardless of whether it was clinically apparent) was relatively uncommon (3.2% at 1-year follow-up in the chlorthalidone group; median dose, 19.0 mg/d).
Dhalla...
FULL TEXT
PDF
Not Available
Citations
Citation

Einhorn PT, Cushman WC, Whelton PK, for the ALLHAT Collaborative Research Group. Chlorthalidone Versus Hydrochlorothiazide. Ann Intern Med. 2013;158:922–923. doi: https://doi.org/10.7326/0003-4819-158-12-201306180-00018

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 2013;158(12):922-923.

DOI: 10.7326/0003-4819-158-12-201306180-00018

1 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×