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Letters |2 July 2013

Successful Treatment of the Postpartum Atypical Hemolytic Uremic Syndrome With Eculizumab

Stefan Zschiedrich, MD; Eric P. Prager, MD; E. Wolfgang Kuehn, MD

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  • From University Hospital Freiburg, Freiburg, Germany.

    Potential Conflicts of Interest: Other (money to institution): Alexion Pharmaceuticals.

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Background: Thrombocytopenia with intravascular hemolysis is a serious complication of pregnancy. When it occurs in the second and third trimesters, it is usually associated with near-absent levels of the ADAMTS13 protease that cleaves von Willebrand factor, a condition that is typical of idiopathic thrombotic thrombocytopenic purpura (1). During pregnancy, approximately 50% of cases of thrombotic thrombocytopenic purpura result in perinatal fetal loss and maternal mortality is also substantial, although plasma exchange has reduced maternal mortality from 58% before 1980 to 9% after 1996 (1). In contrast, when thrombocytopenia with intravascular hemolysis occurs in the postpartum period, ADAMTS13 activity...
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Zschiedrich S, Prager EP, Kuehn EW. Successful Treatment of the Postpartum Atypical Hemolytic Uremic Syndrome With Eculizumab. Ann Intern Med. 2013;159:76. doi: https://doi.org/10.7326/0003-4819-159-1-201307020-00023

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Published: Ann Intern Med. 2013;159(1):76.

DOI: 10.7326/0003-4819-159-1-201307020-00023

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