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ACP Journal Club |20 August 2013

Patent foramen ovale closure and medical therapy did not differ for recurrence after cryptogenic embolism

Mukul Sharma, MD

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Meier B, Kalesan B, Mattle HP, et al: PC Trial Investigators. Percutaneous closure of patent foramen ovale in cryptogenic embolism. N Engl J Med. 2013;368:1083-91. 23514285

Cardiology:

Neurology:

Is closure of patent foramen ovale (PFO) better than medical therapy alone for reducing recurrence after cryptogenic embolism?
Randomized controlled trial (Clinical Trial Comparing Percutaneous Closure of Patent Foramen Ovale [PFO] Using the Amplatzer PFO Occluder with Medical Treatment in Patients with Cryptogenic Embolism [PC Trial]). ClinicalTrials.gov NCT00166257.
Concealed.*
Blinded* (outcome adjudication committee).
5 years (mean 4 y).
29 centers in Australia, Brazil, Canada, and Europe.
414 patients < 60 years of...
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Sharma M. Patent foramen ovale closure and medical therapy did not differ for recurrence after cryptogenic embolism. Ann Intern Med. 2013;159:JC5. doi: https://doi.org/10.7326/0003-4819-159-4-201308200-02005

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Published: Ann Intern Med. 2013;159(4):JC5.

DOI: 10.7326/0003-4819-159-4-201308200-02005

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