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Letters |3 September 2013

Blood Tests to Diagnose Fibrosis or Cirrhosis in Patients With Chronic Hepatitis C Virus Infection

Roger Chou, MD; Ngoc Wasson, MPH

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Although liver biopsy has limitations, such as sampling error and variability in interpretation, it remains the reference standard for evaluating hepatic fibrosis in almost all diagnostic studies. As we reported, results were largely unchanged when analyses were restricted to studies using adequate biopsy specimens (defined as >15 mm in length and >5 portal tracts in the absence of cirrhosis).
We focused on diagnostic rather than prognostic accuracy because determination of fibrosis stage at the time of biopsy affects clinical decisions regarding treatment, and few studies on prognostic performance are available (6 in a recent meta-analysis [1]) compared...
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Chou R, Wasson N. Blood Tests to Diagnose Fibrosis or Cirrhosis in Patients With Chronic Hepatitis C Virus Infection. Ann Intern Med. 2013;159:372. doi: https://doi.org/10.7326/0003-4819-159-5-201309030-00021

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Published: Ann Intern Med. 2013;159(5):372.

DOI: 10.7326/0003-4819-159-5-201309030-00021

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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