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Letters |17 December 2013

Vitamin D and Calcium Supplementation to Prevent Fractures in Adults

Marcus M. Reidenberg, MD

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Author, Article, and Disclosure Information
  • From Weill Cornell Medical College, New York, New York.

    Potential Conflicts of Interest: Board membership: Aminopterin; Patents (planned, pending, or issued): National Institutes of Health; Royalties: National Institutes of Health; Stock/stock options: Ascenta; Travel/accommodations/meeting expenses unrelated to activities listed: United States Pharmacopoeia, U.S. Food and Drug Administration Expert Committee.

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TO THE EDITOR:
I read the USPSTF's guideline (1) with great interest. Both the Institute of Medicine report (2) cited in the editorial (3) and the WHI (Women's Health Initiative) study noted in the guideline as the largest trial of fracture outcomes reported that many persons in the United States are already receiving supplements. Thus, the conclusions refer to persons already having vitamin D and calcium intake at or close to the recommended daily allowance of each, often because they are receiving supplements. Furthermore, the WHI study used the statistical significance value for the intention-to-treat analysis.
I recognize the issue...
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Reidenberg MM. Vitamin D and Calcium Supplementation to Prevent Fractures in Adults. Ann Intern Med. 2013;159:856. doi: https://doi.org/10.7326/0003-4819-159-12-201312170-00015

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Published: Ann Intern Med. 2013;159(12):856.

DOI: 10.7326/0003-4819-159-12-201312170-00015

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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