Skip Navigation
Menu
ACP Journal Club |17 December 2013

Dabigatran increased bleeding and stroke compared with warfarin after mechanical heart valve implantation

Theodore J. Kolias, MD

Article, Author, and Disclosure Information
FULL TEXT
Eikelboom JW, Connolly SJ, Brueckmann M, et al; RE-ALIGN Investigators. Dabigatran versus warfarin in patients with mechanical heart valves. N Engl J Med. 2013;369:1206-14. 23991661

Cardiology:

Does dabigatran prevent thromboembolic complications compared with warfarin after implantation of mechanical heart valves?
Randomized controlled trial (Randomized Phase II Study to Evaluate the Safety and Pharmacokinetics of Oral Dabigatran Etexilate in Patients after Heart Valve Replacement [RE-ALIGN]). ClinicalTrials.gov NCT01452347 and NCT01505881.
Concealed.*
Blinded* (event adjudication committee and echocardiogram analysis).
{Mean 26 weeks; maximum 55 weeks}†. The trial was stopped early for harm.
39 centers in 10 countries.
252 patients 18 to 75 years of age (mean age 56 y, 65% men) who were having a mechanical bileaflet valve implanted in the aortic and/or mitral valve position (n = 199) or who had a mechanical bileaflet mitral valve implanted, with or without aortic valve replacement, > 3 months before randomization (n = 53). Exclusion criteria included uncontrolled hypertension, high risk for bleeding, severe renal impairment, or active liver disease.
FULL TEXT
PDF
Not Available
Citations
Citation

Kolias TJ. Dabigatran increased bleeding and stroke compared with warfarin after mechanical heart valve implantation. Ann Intern Med. 2013;159:JC6. doi: 10.7326/0003-4819-159-12-201312170-02006

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 2013;159(12):JC6.

DOI: 10.7326/0003-4819-159-12-201312170-02006

1 Citations

Related Articles
Update in General Internal Medicine: Evidence Published in 2016
Annals of Internal Medicine; 166 (7): W11-W15
Higher-dose dabigatran reduced stroke, but not major hemorrhage, more than warfarin in atrial fibrillation
Annals of Internal Medicine; 152 (2): JC1-2
Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation: A Systematic Review
Annals of Internal Medicine; 169 (11): 774-787
Risks for Stroke, Bleeding, and Death in Patients With Atrial Fibrillation Receiving Dabigatran or Warfarin in Relation to the CHADS2 Score: A Subgroup Analysis of the RE-LY Trial
Annals of Internal Medicine; 155 (10): 660-667
View MoreView Less

Journal Club
Higher-dose dabigatran reduced stroke, but not major hemorrhage, more than warfarin in atrial fibrillation
Annals of Internal Medicine; 152 (2): JC1-2
In atrial fibrillation, dabigatran had similar efficacy to warfarin but caused less bleeding in higher GFR
Annals of Internal Medicine; 161 (4): JC7
Review: New oral anticoagulants reduced stroke and systemic embolism compared with warfarin in AF
Annals of Internal Medicine; 157 (6): JC3-2
Dabigatran led to less major bleeding than warfarin in younger but not older patients with atrial fibrillation
Annals of Internal Medicine; 155 (6): JC3-3
View MoreView Less

Related Point of Care
Acute Gastrointestinal Bleeding
Annals of Internal Medicine; 159 (3): ITC2-1
Transient Ischemic Attack
Annals of Internal Medicine; 154 (1): ITC1-1
View MoreView Less

Related Topics
Cardiology
Neurology
Stroke
Valvular Heart Disease

Cardiology, Neurology, Stroke, Valvular Heart Disease.

PubMed Articles
Influence of smoking on CYP2C19 genetic variants and clopidogrel efficacy in patients with minor stroke or TIA.
Eur J Neurol 2019.
Meta-analysis of recent literature on utility of follow-up imaging in isolated perimesencephalic hemorrhage.
Clin Neurol Neurosurg 2019;
View More

Results provided by: PubMed

CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×