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Letters |15 April 2014

Triple Therapy for Hepatitis C Virus Infection in Patients Receiving Hemodialysis

Sara Lemoinne, MD; Benoit Barrou, MD; Dominique Thabut, MD

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We read Liu and colleagues’ article (1) with great interest. Cure of hepatitis C virus (HCV) infection is crucial in patients receiving hemodialysis who are awaiting a kidney transplant. Hepatitis C virus infection is associated with decreased survival before and after kidney transplantation (2). However, interferon treatment after transplantation is contraindicated because of a high risk for acute rejection.
Liu and colleagues report results of a randomized trial comparing the efficacy and safety of pegylated interferon plus low-dose ribavirin with those of pegylated interferon monotherapy in 205 treatment-naive patients with HCV infection receiving hemodialysis. They concluded that the virologic response was greater with combination therapy than monotherapy. However, the rate of sustained virologic response with combination therapy was only 64%.
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Lemoinne S, Barrou B, Thabut D. Triple Therapy for Hepatitis C Virus Infection in Patients Receiving Hemodialysis. Ann Intern Med. ;160:581. doi: 10.7326/L14-5008-3

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Published: Ann Intern Med. 2014;160(8):581.

DOI: 10.7326/L14-5008-3

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