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Letters |6 May 2014

Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer

Mark J. Bolland, MBChB, PhD; Andrew Grey, MD; Ian R. Reid, MD

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TO THE EDITOR:
Fortmann and colleagues (1) identified 5 randomized, controlled trials (RCTs) of calcium or vitamin D supplements and cardiovascular disease and cancer. Data were available on all-cause mortality for 3 RCTs of calcium, 1 RCT of vitamin D, and 1 RCT of calcium and vitamin D; cardiovascular disease incidence for 1 RCT of calcium, 2 RCTs of vitamin D, and 1 RCT of calcium and vitamin D; and cancer incidence for 3 RCTs of calcium, 2 RCTs of vitamin D, and 1 RCT of calcium and vitamin D.
In previous systematic reviews of calcium supplementation, we identified 8 RCTs with complete trial-level data available for myocardial infarction, stroke, and all-cause mortality (2) and 7 RCTs with complete trial-level data available for cancer incidence (3). A systematic review by Elamin and associates (4) identified 30 RCTs of vitamin D with data available for mortality, 6 RCTs with data for myocardial infarction, and 6 RCTs with data for stroke. Some of these data were unpublished and provided by the lead authors, but data from other published papers are missing from Fortmann and colleagues’ review.
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Bolland MJ, Grey A, Reid IR. Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer. Ann Intern Med. ;160:655–656. doi: 10.7326/L14-5009-4

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Published: Ann Intern Med. 2014;160(9):655-656.

DOI: 10.7326/L14-5009-4

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