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ACP Journal Club |15 July 2014

Review: Evidence for the effect of vitamin D supplementation on many patient outcomes was assessed

Robert H. Fletcher, MD, MSc

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Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ. 2014;348:g2035. 24690624

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Cardiology:

Rheumatology:

What is the effect of vitamin D supplementation on various outcomes?
Included studies were English-language meta-analyses of vitamin D supplementation compared with placebo, or vitamin D plus another compound (e.g., calcium) compared with the other compound alone; or meta-analyses of observational studies of vitamin D levels. The studies reported any clinical outcome in any population. Exclusion criteria included meta-analyses of observational studies assessing dietary or supplemental vitamin D intake or ultraviolet B exposure; vitamin D status as the outcome; or prevalence of vitamin D deficiency in certain disease populations. Outcomes included cardiovascular (CV) disease; neonatal, infant, or child outcomes; pregnancy outcomes; skeletal outcomes; and mortality.
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Fletcher RH. Review: Evidence for the effect of vitamin D supplementation on many patient outcomes was assessed. Ann Intern Med. 2014;161:JC4. doi: 10.7326/0003-4819-161-2-201407150-02004

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Published: Ann Intern Med. 2014;161(2):JC4.

DOI: 10.7326/0003-4819-161-2-201407150-02004

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