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ACP Journal Club |16 September 2014

Review: Influenza vaccine reduces influenza-like illness in healthy adults

Bruno Granwehr, MD, MS, FACP

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Demicheli V, Jefferson T, Al-Ansary LA, et al. Vaccines for preventing influenza in healthy adults. Cochrane Database Syst Rev. 2014;3:CD001269.

GIM/FP/GP:

Allerg & Immunol:

Infectious Disease:

In healthy adults, what are the efficacy and harms of influenza vaccines?
Included studies compared influenza vaccines (live, attenuated, or killed vaccines) with placebo or no intervention, or different types, doses, or schedules of influenza vaccine in healthy persons 16 to 65 years of age (including pregnant women) and reported on serious adverse events. Studies with > 25% of participants < 16 or > 65 years of age were excluded. Outcomes included influenza-like illness (presenting with specific symptoms or signs of illness), influenza (presenting with specific symptoms or signs of illness plus laboratory confirmation of infection), local adverse effects (induration, soreness, or redness), and serious adverse events (e.g., malaise, nausea, or fever).
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Granwehr B. Review: Influenza vaccine reduces influenza-like illness in healthy adults. Ann Intern Med. ;161:JC6. doi: 10.7326/0003-4819-161-6-201409160-02006

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Published: Ann Intern Med. 2014;161(6):JC6.

DOI: 10.7326/0003-4819-161-6-201409160-02006

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