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ACP Journal Club |21 October 2014

Weekly dalbavancin was noninferior to daily vancomycin for acute bacterial skin infection in adults

Fainareti N. Zervou, MD; Ioannis M. Zacharioudakis, MD; Eleftherios Mylonakis, MD, PhD

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Boucher HW, Wilcox M, Talbot GH, et al. Once-weekly dalbavancin versus daily conventional therapy for skin infection. N Engl J Med. 2014;370:2169-79. 24897082

Hospitalists:

Infectious Disease:

In adults with acute bacterial skin and skin-structure infection (SSSI), is weekly dalbavancin noninferior to daily vancomycin?
2 replicate, randomized, controlled, noninferiority trials (DISCOVER-1 and DISCOVER-2). ClinicalTrials.gov NCT01339091 and NCT01431339.
Concealed.*
Blinded* (patients, clinicians, {data collectors, outcome assessors, data analysts, and safety committee}†).
14 days.
140 investigative sites in the USA, Canada, Europe, South Africa, and Asia.
573 adults in DISCOVER-1 (mean age 49 y, 60% men) and 739 adults in DISCOVER-2 (mean age...
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Zervou FN, Zacharioudakis IM, Mylonakis E. Weekly dalbavancin was noninferior to daily vancomycin for acute bacterial skin infection in adults. Ann Intern Med. 2014;161:JC9. doi: https://doi.org/10.7326/0003-4819-161-8-201410210-02009

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Published: Ann Intern Med. 2014;161(8):JC9.

DOI: 10.7326/0003-4819-161-8-201410210-02009

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