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ACP Journal Club |20 January 2015

Bisphosphonates do not reduce breast cancer in postmenopausal women

Aju Mathew, MD, MPhil; Adam Brufsky, MD, PhD

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Hue TF, Cummings SR, Cauley JA, et al. Effect of bisphosphonate use on risk of postmenopausal breast cancer: results from the randomized clinical trials of alendronate and zoledronic acid. JAMA Intern Med. 2014;174:1550-7. 25111880

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Endocrinology:

Geriatrics:

Do bisphosphonates reduce breast cancer in postmenopausal women treated for osteoporosis?
Post hoc secondary analysis of 2 randomized placebo-controlled trials (Fracture Intervention Trial [FIT] and Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly–Pivotal Fracture Trial [HORIZON-PFT]). ClinicalTrials.gov NCT00049829 (HORIZON-PFT).
Unclear allocation concealment.*
Blinded* (patients, clinicians, and outcome assessors).
4 years (FIT) and 3 years (HORIZON-PFT).
11 academic sites in the USA (FIT); and sites in Asia, the Pacific, Europe, and North and South America (HORIZON-PFT).
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Mathew A, Brufsky A. Bisphosphonates do not reduce breast cancer in postmenopausal women. Ann Intern Med. ;162:JC5. doi: 10.7326/ACPJC-2015-162-2-005

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Published: Ann Intern Med. 2015;162(2):JC5.

DOI: 10.7326/ACPJC-2015-162-2-005

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