Skip Navigation
Menu
ACP Journal Club |20 January 2015

Bisphosphonates do not reduce breast cancer in postmenopausal women

Aju Mathew, MD, MPhil; Adam Brufsky, MD, PhD

Article, Author, and Disclosure Information
FULL TEXT
Hue TF, Cummings SR, Cauley JA, et al. Effect of bisphosphonate use on risk of postmenopausal breast cancer: results from the randomized clinical trials of alendronate and zoledronic acid. JAMA Intern Med. 2014;174:1550-7. 25111880

GIM/FP/GP:

Endocrinology:

Geriatrics:

Do bisphosphonates reduce breast cancer in postmenopausal women treated for osteoporosis?
Post hoc secondary analysis of 2 randomized placebo-controlled trials (Fracture Intervention Trial [FIT] and Health Outcomes and Reduced Incidence with Zoledronic Acid Once Yearly–Pivotal Fracture Trial [HORIZON-PFT]). ClinicalTrials.gov NCT00049829 (HORIZON-PFT).
Unclear allocation concealment.*
Blinded* (patients, clinicians, and outcome assessors).
4 years (FIT) and 3 years (HORIZON-PFT).
11 academic sites in the USA...
FULL TEXT
PDF
Not Available
Citations
Citation

Mathew A, Brufsky A. Bisphosphonates do not reduce breast cancer in postmenopausal women. Ann Intern Med. 2015;162:JC5. doi: https://doi.org/10.7326/ACPJC-2015-162-2-005

Download citation file:

© 2020

×
Permissions

Published: Ann Intern Med. 2015;162(2):JC5.

DOI: 10.7326/ACPJC-2015-162-2-005

0 Citations

Related Articles
In postmenopausal women with breast cancer treated with aromatase inhibitors, denosumab reduced fractures
Annals of Internal Medicine; 163 (6): JC11
Drugs Five Years Later: Calusterone
Annals of Internal Medicine; 89 (6): 945-948
Update in Hematology and Oncology: Evidence Published in 2010
Annals of Internal Medicine; 154 (7): 487-494
Cost-Effectiveness of Different Screening Strategies for Osteoporosis in Postmenopausal Women
Annals of Internal Medicine; 155 (11): 751-761
View MoreView Less

Journal Club
In postmenopausal women with breast cancer treated with aromatase inhibitors, denosumab reduced fractures
Annals of Internal Medicine; 163 (6): JC11
In postmenopausal women with osteoporosis, romosozumab followed by alendronate reduced fractures vs alendronate alone
Annals of Internal Medicine; 168 (2): JC3
Pooled RCTs: In postmenopausal women, hormone therapy for 6 to 7 years did not affect mortality at 18 years
Annals of Internal Medicine; 168 (2): JC4
Review: Different bisphosphonates are equally effective and safe for preventing fragility fractures
Annals of Internal Medicine; 166 (6): JC34
View MoreView Less

Related Point of Care
Breast Cancer Screening and Prevention
Annals of Internal Medicine; 164 (11): ITC81-ITC96
Breast Cancer Screening and Prevention
Annals of Internal Medicine; 152 (7): ITC4-1
View MoreView Less

Related Topics
Breast Cancer
Hematology/Oncology

Breast Cancer, Hematology/Oncology.

PubMed Articles
Using an electronic self-completion tool to identify patients at increased risk of melanoma in Australian primary care.
Australas J Dermatol 2020.
The burden of chronic diseases among Australian cancer patients: Evidence from a longitudinal exploration, 2007-2017.
PLoS One 2020;15(2):e0228744.
View More

Results provided by: PubMed

CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2020 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×