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ACP Journal Club |21 April 2015

Glyceryl trinitrate did not improve functional outcome in patients with acute stroke and high BP

Graeme J. Hankey, MBBS

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ENOS Trial Investigators. Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet. 2015;385:617-28. 25465108

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In patients with acute stroke and high blood pressure (BP), does glyceryl trinitrate (nitric oxide) safely improve outcomes? What are the effects of continuing versus stopping antihypertensive drugs?
Partial 2 x 2 factorial, randomized, controlled trial (RCT) (Efficacy of Nitric Oxide in Stroke [ENOS] trial). Current Controlled Trials ISRCTN99414122.
Concealed.*
Blinded* (for glyceryl trinitrate: patients, data collectors, and outcome assessors; for antihypertensive drugs: data collectors and outcome assessors).
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Hankey GJ. Glyceryl trinitrate did not improve functional outcome in patients with acute stroke and high BP. Ann Intern Med. ;162:JC12. doi: 10.7326/ACPJC-2015-162-8-012

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Published: Ann Intern Med. 2015;162(8):JC12.

DOI: 10.7326/ACPJC-2015-162-8-012

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