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Letters |19 May 2015

Screening for Vitamin D Deficiency: Is the Goal Disease Prevention or Full Nutrient Repletion?

Arthur B. Chausmer, MD, PhD

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TO THE EDITOR:
We read Heaney and Armas' editorial (1) about the assessment of and need for vitamin D supplementation with great interest. The pathologic hallmark of vitamin D insufficiency is an increase in uncalcified osteoid organic matrix in bone. The clinical hallmarks of this condition are specific findings, such as Milkman fractures, or unmineralized osteoid on undecalcified bone biopsy specimens. Neither hypocalcemia nor osteoporosis—which causes uniform loss of organic and mineralized bone and is a disorder of architecture, not calcification—is a hallmark of vitamin D deficiency. Virtually no direct clinical evidence of vitamin D deficiency in the...
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Chausmer AB. Screening for Vitamin D Deficiency: Is the Goal Disease Prevention or Full Nutrient Repletion?. Ann Intern Med. 2015;162:738–739. doi: 10.7326/L15-5095

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Published: Ann Intern Med. 2015;162(10):738-739.

DOI: 10.7326/L15-5095

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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