Skip Navigation
Menu
Editorials |4 August 2015

Pregnancy in Women With Systemic Lupus Erythematosus: Messages for the Clinician

Bevra H. Hahn, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
This article was published online first at www.annals.org on 23 June 2015.
  • From David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

    Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-1301.

    Requests for Single Reprints: Bevra H. Hahn, MD, Distinguished Professor of Medicine (Emeritus), Division of Rheumatology, David Geffen School of Medicine, University of California, Los Angeles, Room 31-75, 1000 Veteran Avenue, Los Angeles, CA 90095.

×
FULL TEXT
In this issue, Buyon and colleagues (1) report findings from the PROMISSE (Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus) study, a large prospective study of pregnancy outcomes in women with systemic lupus erythematosus (SLE). The study involved 8 centers in the United States and 1 in Canada serving patients of diverse socioeconomic status and ethnicity. The restrictions for study entry are important to note. Patients were required to have reached at least 12 weeks of a singleton gestation; have inactive SLE or mild to moderate SLE activity; be free of heavy proteinuria, microscopic hematuria, and abnormal serum creatinine levels; not be receiving a prednisone dose greater than 20 mg/d; and be free of diabetes and uncontrolled hypertension. However, despite the limited study population, the article contains valuable information for clinicians who have the joy and challenge of participating in the medical management of these women.
First, the good news. Among the women studied, pregnancy outcomes were good in 81%, meaning that the infant was born alive, survived the neonatal period, was delivered after at least 36 weeks' gestation, and was in at least the fifth percentile for birthweight. This is similar to the outcome in another recent North American cohort (2). Furthermore, the PROMISSE study identified characteristics of U.S. women who had optimal outcomes. A successful pregnancy outcome was achieved by 92% of non-Hispanic white women with negative lupus anticoagulant test results, no treatment for hypertension, no or low disease...
FULL TEXT
PDF
Not Available
Citations
Citation

Hahn BH. Pregnancy in Women With Systemic Lupus Erythematosus: Messages for the Clinician. Ann Intern Med. 2015;163:232–233. doi: https://doi.org/10.7326/M15-1301

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 2015;163(3):232-233.

DOI: 10.7326/M15-1301

1 Citations

Related Articles
Systemic Lupus Erythematosus: Emerging Concepts: Part 2: Dermatologic and Joint Disease, the Antiphospholipid Antibody Syndrome, Pregnancy and Hormonal Therapy, Morbidity and Mortality, and Pathogenesis
Annals of Internal Medicine; 123 (1): 42-53
Predictors of Pregnancy Outcomes in Patients With Lupus: A Cohort Study
Annals of Internal Medicine; 163 (3): 153-163
Diagnosis of Pulmonary Embolism During Pregnancy: A Multicenter Prospective Management Outcome Study
Annals of Internal Medicine; 169 (11): 766-773
β-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study
Annals of Internal Medicine; 169 (10): 665-673
View MoreView Less

Journal Club
Guideline: Recommendations are provided for antiretroviral therapies in pregnant women with HIV
Annals of Internal Medicine; 168 (4): JC14
Modified Framingham Risk Score predicted 10-y CAD better than the original score in patients with lupus
Annals of Internal Medicine; 164 (12): JC71
In high-risk pregnant women, an individualized lifestyle intervention reduced gestational diabetes mellitus
Annals of Internal Medicine; 163 (12): JC7
In unexplained recurrent pregnancy loss, daily LMWH did not improve ongoing pregnancy or live birth rates
Annals of Internal Medicine; 163 (6): JC10
View MoreView Less

Related Point of Care
Systemic Lupus Erythematosus
Annals of Internal Medicine; 159 (7): ITC4-1
View MoreView Less

Related Topics
Lupus Erythematosus
Rheumatology

Lupus Erythematosus, Rheumatology.

PubMed Articles
Sonographic characteristics of the placenta, uterine wall, and placentomes during pregnancy in cows.
Tierarztl Prax Ausg G Grosstiere Nutztiere 2019;47(6):355-365.
Neonatal developmental and behavioral outcomes of immediate delivery versus expectant monitoring in mild hypertensive disorders of pregnancy: 5-year outcomes of the HYPITAT II trial.
Eur J Obstet Gynecol Reprod Biol 2019;
View More

Results provided by: PubMed

CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×