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Letters |7 July 2015

Anakinra Improves Pyoderma Gangrenosum in Psoriatic Arthritis: A Case Report

Marie Acquitter, MD; Patrice Plantin, MD; Ingrid Kupfer, MD; Henri Auvinet, BS; Thierry Marhadour, MD

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Background: Anakinra is an antagonist of the receptor for interleukin-1. Pyoderma gangrenosum is a poorly understood condition that causes necrosis of skin and other tissue.
Objective: To report the first case to our knowledge of anakinra improving pyoderma gangrenosum in a patient with psoriatic arthritis.
Case Report: We assumed the care of a 46-year-old white woman with a painful, deep ulcer in the left leg. She was diagnosed with plaque psoriasis at age 7 years and had experienced symmetrical, destructive axial and peripheral polyarthritis since age 18 years. She was negative for rheumatoid factor and anti–cyclic citrullinated peptide antibodies but...
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Acquitter M, Plantin P, Kupfer I, et al. Anakinra Improves Pyoderma Gangrenosum in Psoriatic Arthritis: A Case Report. Ann Intern Med. 2015;163:70–71. doi: 10.7326/L15-5107

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Published: Ann Intern Med. 2015;163(1):70-71.

DOI: 10.7326/L15-5107

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