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ACP Journal Club |18 August 2015

Transcatheter aortic valve replacement reduced mortality more than usual care in inoperable severe aortic stenosis

James Brophy, MD, PhD

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Kapadia SR, Leon MB, Makkar RR, et al; PARTNER trial investigators. 5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet. 2015 Mar 15. Epub ahead of print. 25788231

Cardiology:

In inoperable patients with severe symptomatic aortic stenosis, does transcatheter aortic valve replacement (TAVR) reduce mortality compared with usual care?
Follow-up of a randomized controlled trial (RCT) (Placement of Aortic Transcatheter Valves [PARTNER] study). ClinicalTrials.gov NCT00530894.
Concealed.*
Blinded* (cause of death adjudicators).
5 years.
21 valve centers in the USA, Canada, and Germany.
358 patients (mean age 83 y, 54% women) who had severe symptomatic aortic stenosis (aortic valve area < 0.8 cm2) and clinical or anatomical factors that precluded surgical aortic valve replacement.
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Brophy J. Transcatheter aortic valve replacement reduced mortality more than usual care in inoperable severe aortic stenosis. Ann Intern Med. 2015;163:JC4. doi: 10.7326/ACPJC-2015-163-4-004

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Published: Ann Intern Med. 2015;163(4):JC4.

DOI: 10.7326/ACPJC-2015-163-4-004

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