Skip Navigation
Menu
Letters |15 September 2015

Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss

Rucha Patil, MSc; Kanjaksha Ghosh, MD; Shrimati Shetty, PhD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
×
FULL TEXT
TO THE EDITOR:
We read Schleussner and colleagues' article (1) about the effect of low-molecular-weight-heparin (LMWH) on pregnancy outcomes in women with unexplained pregnancy loss with interest. On the basis of the absence of a significant difference in the live-birth rates between women who are and those who are not receiving anticoagulant therapy, the authors do not recommended anticoagulation in such women. A similar observation has been reported in a double-blind, placebo-controlled trial using enoxaparin (2). However, while applying the exclusion criteria for different acquired and inherited types of thrombophilia, one should consider the recently emerged prothrombotic marker—that is, cell-derived microparticles (MPs), which are basically markers of activation and cell death. Because most MPs express phosphatidylserine on their surface, they become thrombogenic. Elevated MP levels in any clinical condition thus suggest some type of chronic activation or damage. The procoagulant nature of MPs is proved by the decrease in clotting time when MP-rich plasma is added to a test system and confirmed by their strong association with different thrombotic disorders.
FULL TEXT
PDF
Not Available
Citations
Citation

Patil R, Ghosh K, Shetty S. Low-Molecular-Weight Heparin for Women With Unexplained Recurrent Pregnancy Loss. Ann Intern Med. ;163:483–484. doi: 10.7326/L15-5137

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 2015;163(6):483-484.

DOI: 10.7326/L15-5137

0 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×