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ACP Journal Club |17 November 2015

Review: In older patients with AF or acute VTE, some DOACs reduce thrombotic events and major bleeding

Richard H. White, MD

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Sharma M, Cornelius VR, Patel JP, Davies JG, Molokhia M. Efficacy and harms of direct oral anticoagulants in the elderly for stroke prevention in atrial fibrillation and secondary prevention of venous thromboembolism: systematic review and meta-analysis. Circulation. 2015;132:194-204. 25995317

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Cardiology:

Gastroenterology:

Geriatrics:

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In older patients with atrial fibrillation (AF) or acute venous thromboembolism (VTE), what are the efficacy and safety of direct oral anticoagulants (DOACs) compared with vitamin K antagonists (VKA)?
Included English studies compared DOACs (thrombin inhibitor dabigatran or factor Xa inhibitors apixaban, rivaroxaban, and edoxaban) with a VKA for stroke prevention in patients with AF or for treatment of acute VTE for ≥ 3 months. Primary outcomes were stroke or systemic embolism, recurrent VTE, and major bleeding.
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White RH. Review: In older patients with AF or acute VTE, some DOACs reduce thrombotic events and major bleeding. Ann Intern Med. ;163:JC4. doi: 10.7326/ACPJC-2015-163-10-004

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Published: Ann Intern Med. 2015;163(10):JC4.

DOI: 10.7326/ACPJC-2015-163-10-004

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