Skip Navigation
Menu
Editorials |5 January 2016

Evaluating Hepatitis B Virus Reactivation During Solid Tumor Chemotherapy: Evidence to Guide Pretreatment Hepatitis B Screening and Prophylaxis

Vincent Lo Re III, MD, MSCE; Mindy Schuster, MD, MSCE

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
This article was published online first at www.annals.org on 24 November 2015.
  • From University of Pennsylvania, Philadelphia, Pennsylvania.

    Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-2722.

    Requests for Single Reprints: Vincent Lo Re III, MD, MSCE, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, 836 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104; e-mail, vincentl@mail.med.upenn.edu.

    Current Author Addresses: Dr. Lo Re: Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, 836 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104.

    Dr. Schuster: Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3 Silverstein, Suite E, 3400 Spruce Street, Philadelphia, PA 19104.

×
FULL TEXT
Reactivation of hepatitis B virus (HBV) infection is increasingly recognized as a complication of immunosuppressive therapy, particularly chemotherapy. It is characterized by an abrupt increase in HBV DNA level among patients with positive hepatitis B surface antigen (HBsAg) or the reappearance of serum HBV DNA in those with serologic evidence of resolved infection (negative HBsAg and positive core antibody [HBcAb] with or without HBV surface antibody). It is usually accompanied by elevations in liver aminotransferase levels. Reactivation can lead to serious hepatic injury, chemotherapy interruption, liver failure, and death (1).
Reactivation of HBV occurs because after infection, the virus establishes covalently closed circular DNA as a durable miniature chromosome within the nuclei of infected hepatocytes during replication. Because HBV closed circular DNA persists, even after serologic resolution of infection, acquired immunosuppression can disrupt the ability of the host immune system to control HBV replication and result in reactivation.
FULL TEXT
PDF
Not Available
Citations
Citation

Lo Re V, Schuster M. Evaluating Hepatitis B Virus Reactivation During Solid Tumor Chemotherapy: Evidence to Guide Pretreatment Hepatitis B Screening and Prophylaxis. Ann Intern Med. ;164:64–65. doi: 10.7326/M15-2722

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 2016;164(1):64-65.

DOI: 10.7326/M15-2722

Published at www.annals.org on 24 November 2015

5 Citations

Related Articles
Hepatitis B Virus Reactivation and Prophylaxis During Solid Tumor Chemotherapy: A Systematic Review and Meta-analysis
Annals of Internal Medicine; 164 (1): 30-40
Prevention of Vertical Transmission of Hepatitis B: An Observational Study
Annals of Internal Medicine; 160 (12): 828-835
Systematic Review: The Effect of Preventive Lamivudine on Hepatitis B Reactivation during Chemotherapy
Annals of Internal Medicine; 148 (7): 519-528
Hepatitis B Vaccination, Screening, and Linkage to Care: Best Practice Advice From the American College of Physicians and the Centers for Disease Control and Prevention
Annals of Internal Medicine; 167 (11): 794-804
View MoreView Less

Journal Club
Semuloparin reduced venous thromboembolism in patients receiving chemotherapy for cancer
Annals of Internal Medicine; 156 (12): JC6-5
View MoreView Less

Related Topics
Gastroenterology/Hepatology
Infectious Disease
Liver Disease
Viral Hepatitis

Gastroenterology/Hepatology, Infectious Disease, Liver Disease, Viral Hepatitis.

PubMed Articles
Somatostatin Receptor Ligand Therapy-A Novel Therapy for Neurocytoma.
J Clin Endocrinol Metab 2019.
Gilteritinib: First Global Approval.
Drugs 2019.
View More

Results provided by: PubMed

CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×