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ACP Journal Club |15 December 2015

In HIV-1, immediate vs deferred antiretroviral therapy and isoniazid vs no isoniazid reduced severe illness at 30 mo

Fiona Smaill, MSc, FRACP, FRCPC

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TEMPRANO ANRS 12136 Study Group, Danel C, Moh R, et al. A trial of early antiretrovirals and isoniazid preventive therapy in Africa. N Engl J Med. 2015;373:808-22. 26193126

Infectious Disease:

Pulmonology:

In adults with HIV-1 infection, does immediate antiretroviral therapy (ART) reduce severe illness compared with deferred ART? Does isoniazid preventive therapy (IPT) reduce severe illness compared with no IPT?
Randomized, controlled, 2 x 2 factorial trial (TEMPRANO ANRS 12136 trial). ClinicalTrials.gov NCT00495651.
Concealed.*
Unblinded.*
30 months.
9 centers in Abidjan, Ivory Coast.
2076 patients ≥ 18 years of age (median age 35 y, 79% women, median CD4+ count 459 to 467 cells/mm3) who had HIV-1 infection or dual HIV-1 and HIV-2 infection, CD4+ count < 800 cells/mm3, and did not meet World Health Organization (WHO) criteria for starting ART.
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Smaill F. In HIV-1, immediate vs deferred antiretroviral therapy and isoniazid vs no isoniazid reduced severe illness at 30 mo. Ann Intern Med. ;163:JC5. doi: 10.7326/ACPJC-2015-163-12-005

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Published: Ann Intern Med. 2015;163(12):JC5.

DOI: 10.7326/ACPJC-2015-163-12-005

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