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ACP Journal Club |15 December 2015

Review: Combination umeclidinium/vilanterol improved health status more than umeclidinium in COPD

Matthew B. Stanbrook, MD, PhD

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Rodrigo GJ, Neffen H. A systematic review of the efficacy and safety of a fixed-dose combination of umeclidinium and vilanterol for the treatment of COPD. Chest. 2015;148:397-407. 25798635

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Pulmonology:

In adults with chronic obstructive pulmonary disease (COPD), what are the relative efficacy and safety of combination umeclidinium/vilanterol (UMEC/VIL) and its monocomponents, tiotropium, or fluticasone propionate/salmeterol (FSC)?
Included studies compared UMEC/VIL with UMEC, VIL, tiotropium, or FSC in adults ≥ 40 years of age who had stable moderate to very severe COPD and reported a relevant outcome. Outcomes included health status (St. George's Respiratory Questionnaire total score, minimal clinically important difference ≥ 4 points), exacerbations, dyspnea (Transition Dyspnea Index total score, minimal clinically important difference ≥ 1 point), pulmonary function (trough FEV1), serious adverse events (SAEs), and serious cardiovascular events (SCVEs). Prospero International Prospective Register of Systematic Reviews CRD42014015463.
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Stanbrook MB. Review: Combination umeclidinium/vilanterol improved health status more than umeclidinium in COPD. Ann Intern Med. ;163:JC10. doi: 10.7326/ACPJC-2015-163-12-010

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Published: Ann Intern Med. 2015;163(12):JC10.

DOI: 10.7326/ACPJC-2015-163-12-010

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