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ACP Journal Club |16 February 2016

Review: In rheumatoid arthritis, TNF-α inhibitors do not differ from placebo or DMARDs for all-cause mortality

Ami Schattner, MD

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Poiroux L, Allanore Y, Kahan A, Avouac J. All-cause mortality associated with TNF-alpha inhibitors in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Am J Med. 2015. [Epub ahead of print] 26247564

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Rheumatology:

In adults with rheumatoid arthritis (RA), what is the effect of tumor necrosis factor (TNF)-α inhibitors on all-cause mortality?
Included English-language studies compared available TNF-α inhibitors (adalimumab, etanercept, certolizumab, infliximab, or golimumab) with placebo or disease-modifying antirheumatic drugs (DMARDs) for ≥ 24 weeks in adults with RA. Primary outcome was all-cause mortality.
MEDLINE, EMBASE/Excerpta Medica, Cochrane Library, Google Scholar (all Jan 2000 to Nov 2014), and...
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Schattner A. Review: In rheumatoid arthritis, TNF-α inhibitors do not differ from placebo or DMARDs for all-cause mortality. Ann Intern Med. 2016;164:JC20. doi: https://doi.org/10.7326/ACPJC-2016-164-4-020

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Published: Ann Intern Med. 2016;164(4):JC20.

DOI: 10.7326/ACPJC-2016-164-4-020

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