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ACP Journal Club |15 March 2016

Review: Mammography screening reduces breast cancer mortality in women at average risk

Joann G. Elmore, MD, MPH

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Myers ER, Moorman P, Gierisch JM, et al. Benefits and harms of breast cancer screening: a systematic review. JAMA. 2015;314:1615-34. 26501537

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Q1: In women ≥ 40 years of age at average risk for breast cancer, what are the benefits and harms of mammography screening? Q2: Do the benefits and harms vary by screening interval or age? Q3: In women ≥ 20 years of age at average risk, what are the benefits and harms of clinical breast examination (CBE) alone or with mammography?
Included studies compared mammography with no screening in women ≥ 40 years of age with no known risk factors (Q1 and 2) or CBE with no screening in women ≥ 20 years of age with no known risk factors (Q3). Studies of women with breast cancer susceptibility genes; family history of breast cancer; or previous chest irradiation, ductal carcinoma in situ, lobular neoplasia, invasive breast cancer, or abnormal pathology; or studies that included men were excluded. Outcomes included breast cancer mortality, and false-positive results leading to biopsy recommendations (FPB) (Q1 and 2); and case-fatality and all false-positive results (Q3).
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Elmore JG. Review: Mammography screening reduces breast cancer mortality in women at average risk. Ann Intern Med. ;164:JC26. doi: 10.7326/ACPJC-2016-164-6-026

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Published: Ann Intern Med. 2016;164(6):JC26.

DOI: 10.7326/ACPJC-2016-164-6-026

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2016 American College of Physicians
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