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ACP Journal Club |18 October 2016

In postmenopausal women, oral but not transdermal estrogen was associated with increased risk for stroke

Susan M. Ott, MD

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Canonico M, Carcaillon L, Plu-Bureau G, et al. Postmenopausal hormone therapy and risk of stroke: impact of the route of estrogen administration and type of progestogen. Stroke. 2016;47:1734-41. 27256671

GIM/FP/GP:

Endocrinology:

Hematol/Thrombo:

In postmenopausal women, is hormone therapy (HT) linked to increased risk for stroke? Does risk differ by method of estrogen administration?
Nested case–control study using data from linked national health care databases.
France.
3144 women 51 to 62 years of age (mean age 57 y) who had a first hospitalization for ischemic stroke between Apr 2009 and Dec 2011 (index date = date of hospitalization). Exclusion criteria included...
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Ott SM. In postmenopausal women, oral but not transdermal estrogen was associated with increased risk for stroke. Ann Intern Med. 2016;165:JC46. doi: 10.7326/ACPJC-2016-165-8-046

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Published: Ann Intern Med. 2016;165(8):JC46.

DOI: 10.7326/ACPJC-2016-165-8-046

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2016 American College of Physicians
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